BindingDB PrimarySearch

BDBM50065640 CHEMBL3401455

SMILES: Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-n2cncn2)c1

InChI Key: InChIKey=GAVZCGTYRWKKDV-UHFFFAOYSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50065640
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Monoglyceride lipase (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	209	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 10 mins by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 30 mins by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	257	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 60 mins by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	309	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Reversible inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid after 90 mins by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human recombinant MAGL using 2-arachidonoylglycerol substrate assessed as arachidonic acid by HPLC analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counti...				Bioorg Med Chem 23: 6335-45 (2015) BindingDB Entry DOI: 10.7270/Q2NP266B
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoacylglycerol lipase ABHD6 (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human ABHD6 containing pCMV6-AC-hABHD6 transfected into HEK293 cells				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoacylglycerol lipase ABHD6 (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human ABHD6 expressed in HEK293 cells assessed as reduction in glycerol production from 1-AG hydrolysis pre-incubated for 30 mins befor...				Bioorg Med Chem 23: 6335-45 (2015) BindingDB Entry DOI: 10.7270/Q2NP266B
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoacylglycerol lipase ABHD6 (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human ABHD6 expressed in HEK293 cells assessed as reduction in glycerol production from 1-AG hydrolysis pre-incubated for 30 mins befor...				Bioorg Med Chem 23: 6335-45 (2015) BindingDB Entry DOI: 10.7270/Q2NP266B
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human MAGL expressed in HEK293 cells pre-incubated for 10 mins before 2-AG substrate addition by HPLC method				Bioorg Med Chem 23: 6335-45 (2015) BindingDB Entry DOI: 10.7270/Q2NP266B
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counti...				Bioorg Med Chem 23: 6335-45 (2015) BindingDB Entry DOI: 10.7270/Q2NP266B
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50065640 (CHEMBL3401455) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Eastern Finland Curated by ChEMBL					Assay Description Inhibition of human FAAH using [ethanolamine 1-3H] substrate assessed as radioactivity by liquid scintillation counting analysis				Bioorg Med Chem Lett 25: 1436-42 (2015) Article DOI: 10.1016/j.bmcl.2015.02.037 BindingDB Entry DOI: 10.7270/Q20Z74Z4
University of Eastern Finland Curated by ChEMBL					More data for this Ligand-Target Pair