BindingDB PrimarySearch

BDBM50065796 (E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid::2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid::2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid::2-[2-((E)-3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid::2-[2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid::CHEMBL39092

SMILES: OC(=O)c1ccc2ccc(\C=C\c3ccc(O)c(O)c3)nc2c1O

InChI Key: InChIKey=XQDVWYSATRRSMJ-ORCRQEGFSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50065796
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UMR 8076 Curated by ChEMBL					Assay Description In vitro inhibition of recombinant integrase activity in a standard 3'-processing assay.				Bioorg Med Chem Lett 14: 2473-6 (2004) Article DOI: 10.1016/j.bmcl.2004.03.005 BindingDB Entry DOI: 10.7270/Q2RX9BH1
CNRS UMR 8076 Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description In vitro anti-HIV integrase activity of the compound was tested against integration(strand transfer) of target plasmid.				J Med Chem 41: 2846-57 (1998) Article DOI: 10.1021/jm980043e BindingDB Entry DOI: 10.7270/Q21Z43JH
Université Paris-Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description HIV integrase inhibitory potency of the compound was evaluated as IC50 on 3' processing of target DNA.				J Med Chem 41: 2846-57 (1998) Article DOI: 10.1021/jm980043e BindingDB Entry DOI: 10.7270/Q21Z43JH
Université Paris-Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description Inhibitory activity against Integrase in 3'-end- processing				J Med Chem 43: 1533-40 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PNQ
Université Paris-Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description Inhibitory activity against Integrase in strand transfer(integration)				J Med Chem 43: 1533-40 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PNQ
Université Paris-Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jadavpur University Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase 3' processing activity				Eur J Med Chem 43: 81-92 (2008) Article DOI: 10.1016/j.ejmech.2007.02.021 BindingDB Entry DOI: 10.7270/Q24170XZ
Jadavpur University Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Unité Associée au CNRS Curated by ChEMBL					Assay Description In vitro inhibitory concentration against HIV-1 recombinant integrase activity in strand transfer assay				Bioorg Med Chem Lett 15: 4019-22 (2005) Article DOI: 10.1016/j.bmcl.2005.06.036 BindingDB Entry DOI: 10.7270/Q2GM86VW
Unité Associée au CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Paris Sud Curated by ChEMBL					Assay Description Inhibition of PIM1				Bioorg Med Chem Lett 20: 2801-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.061 BindingDB Entry DOI: 10.7270/Q2125STS
Universit£ Paris Sud Curated by ChEMBL					More data for this Ligand-Target Pair
Rous sarcoma virus integrase (Rous sarcoma virus (strain Prague C) (RSV-PrC))	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UMR 8532 Curated by ChEMBL					Assay Description Inhibition of rous sarcoma virus (RSV) Integrase.				J Med Chem 43: 1949-57 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2RB759N
CNRS UMR 8532 Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UMR 8532 Curated by ChEMBL					Assay Description Inhibition of human immunodeficiency virus-1 (HIV-1) integrase.				J Med Chem 43: 1949-57 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2RB759N
CNRS UMR 8532 Curated by ChEMBL					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	6.17E+12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Human immunodeficiency virus 1 integrase strand transfer activity				Citation and Details Article DOI: 10.1007/s00044-011-9593-5 BindingDB Entry DOI: 10.7270/Q26976G0
TBA					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50065796 ((E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-c...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Unité Associée au CNRS Curated by ChEMBL					Assay Description In vitro inhibitory concentration against HIV-1 recombinant integrase activity in standard 3'-processing assay				Bioorg Med Chem Lett 15: 4019-22 (2005) Article DOI: 10.1016/j.bmcl.2005.06.036 BindingDB Entry DOI: 10.7270/Q2GM86VW
Unité Associée au CNRS Curated by ChEMBL					More data for this Ligand-Target Pair