BDBM50072063 3-(4-Methanesulfonyl-phenyl)-5-trifluoromethyl-[2,3']bipyridinyl::CHEMBL92759

SMILES: CS(=O)(=O)c1ccc(cc1)-c1cc(cnc1-c1cccnc1)C(F)(F)F

InChI Key: InChIKey=DBYDCJSATBOJOK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50072063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase/G/H synthase 2 (Homo sapiens (Human))	BDBM50072063 (3-(4-Methanesulfonyl-phenyl)-5-trifluoromethyl-[2,...) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(cnc1-c1cccnc1)C(F)(F)F Show InChI InChI=1S/C18H13F3N2O2S/c1-26(24,25)15-6-4-12(5-7-15)16-9-14(18(19,20)21)11-23-17(16)13-3-2-8-22-10-13/h2-11H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of Prostaglandin G/H synthase 2 was measured by the inhibition of PGE-2 produced by lipopolysaccharide-challenged HWB				Bioorg Med Chem Lett 8: 2777-82 (1999) BindingDB Entry DOI: 10.7270/Q2FX78M0
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50072063 (3-(4-Methanesulfonyl-phenyl)-5-trifluoromethyl-[2,...) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(cnc1-c1cccnc1)C(F)(F)F Show InChI InChI=1S/C18H13F3N2O2S/c1-26(24,25)15-6-4-12(5-7-15)16-9-14(18(19,20)21)11-23-17(16)13-3-2-8-22-10-13/h2-11H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2				Bioorg Med Chem Lett 8: 2777-82 (1999) BindingDB Entry DOI: 10.7270/Q2FX78M0
					More data for this Ligand-Target Pair
Cyclooxygenase-1 (COX-1) (Homo sapiens (Human))	BDBM50072063 (3-(4-Methanesulfonyl-phenyl)-5-trifluoromethyl-[2,...) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(cnc1-c1cccnc1)C(F)(F)F Show InChI InChI=1S/C18H13F3N2O2S/c1-26(24,25)15-6-4-12(5-7-15)16-9-14(18(19,20)21)11-23-17(16)13-3-2-8-22-10-13/h2-11H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells at subsaturating arachidoni...				Bioorg Med Chem Lett 8: 2777-82 (1999) BindingDB Entry DOI: 10.7270/Q2FX78M0
					More data for this Ligand-Target Pair