BDBM50074898 2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-pyridin-2-yl]-4-pyridin-3-yl-2H-phthalazin-1-one; hydrochloride::CHEMBL543016
SMILES: COc1cc2cc(CO)cc(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
InChI Key: InChIKey=PVROZLBFLOWVPM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 4 (Homo sapiens (Human)) | BDBM50074898 (2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of rolipram binding to phosphodiesterase 4 | Bioorg Med Chem Lett 13: 2347-50 (2003) BindingDB Entry DOI: 10.7270/Q2HQ4236 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 4 (Homo sapiens (Human)) | BDBM50074898 (2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL | Assay Description In vitro inhibition of Phosphodiesterase 4 from guinea pig lung | J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 4 (Homo sapiens (Human)) | BDBM50074898 (2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of phosphodiesterase 4 | Bioorg Med Chem Lett 13: 2347-50 (2003) BindingDB Entry DOI: 10.7270/Q2HQ4236 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50074898 (2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL | Assay Description In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle | J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50074898 (2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL | Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung | J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH | |||||||||||
More data for this Ligand-Target Pair |