BDBM50075473 CHEMBL3415305
SMILES: Cl.OCCCNCCCc1ccc(Cl)c(c1)C(=O)NCC12CC3CC(CC(C3)C1)C2
InChI Key: InChIKey=LZBBHFRRZLDHLE-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 7 (Mus musculus) | BDBM50075473![]() (CHEMBL3415305) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL | Assay Description Antagonist activity at P2X7 receptor in LPS-primed mouse J774.A1 cells assessed as inhibition of ATP-induced IL-1beta release after 30 mins by ELISA | J Med Chem 58: 2114-34 (2015) Article DOI: 10.1021/jm500324g BindingDB Entry DOI: 10.7270/Q2H133QD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50075473![]() (CHEMBL3415305) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL | Assay Description Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced EtBr uptake measured after 2 hrs by fluo... | J Med Chem 59: 7410-30 (2016) Article DOI: 10.1021/acs.jmedchem.5b01690 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50075473![]() (CHEMBL3415305) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL | Assay Description Antagonist activity at human P2X7 receptor in LPS/IFN-gamma-differentiated human THP-1 cells assessed as suppression of BzATP-stimulated IL-1beta rel... | J Med Chem 59: 7410-30 (2016) Article DOI: 10.1021/acs.jmedchem.5b01690 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50075473![]() (CHEMBL3415305) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL | Assay Description Antagonist activity at human P2X7 receptor | J Med Chem 59: 7410-30 (2016) Article DOI: 10.1021/acs.jmedchem.5b01690 | |||||||||||
More data for this Ligand-Target Pair |