BindingDB PrimarySearch

BDBM50076296 (4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-phenyl)-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one::CHEMBL286158

SMILES: C[C@H]1C(=O)C(C)(C)Nc2ccc3-c4ccccc4O[C@@H](c4cccc(c4)C(F)(F)F)c3c12

InChI Key: InChIKey=FZORYLRILGENBG-FATZIPQQSA-N

Data: 3 KI 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50076296
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50076296 ((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	123	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptor				J Med Chem 42: 1466-72 (1999) Article DOI: 10.1021/jm980723h BindingDB Entry DOI: 10.7270/Q2NK3FQ9
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50076296 ((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against baculovirus expressed human glucocorticoid receptor (hGR)				J Med Chem 42: 1466-72 (1999) Article DOI: 10.1021/jm980723h BindingDB Entry DOI: 10.7270/Q2NK3FQ9
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50076296 ((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	807	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against baculovirus expressed human androgen receptor (hAR)				J Med Chem 42: 1466-72 (1999) Article DOI: 10.1021/jm980723h BindingDB Entry DOI: 10.7270/Q2NK3FQ9
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50076296 ((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells				J Med Chem 42: 1466-72 (1999) Article DOI: 10.1021/jm980723h BindingDB Entry DOI: 10.7270/Q2NK3FQ9
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50076296 ((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	63	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cells				J Med Chem 42: 1466-72 (1999) Article DOI: 10.1021/jm980723h BindingDB Entry DOI: 10.7270/Q2NK3FQ9
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair