BDBM50079082 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-phenylmethanesulfonyl-piperidin-4-yl)-ethanone::CHEMBL328743

SMILES: Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)S(=O)(=O)Cc3ccccc3)c3ncc(Br)cc3CCc2c1

InChI Key: InChIKey=FFNXZDBGNUKYOO-JGCGQSQUSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50079082   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50079082 (1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...) Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)S(=O)(=O)Cc3ccccc3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C33H36Br2ClN3O3S/c34-27-17-26-7-6-25-18-28(36)19-29(35)31(25)32(33(26)37-20-27)24-10-12-38(13-11-24)30(40)16-22-8-14-39(15-9-22)43(41,42)21-23-4-2-1-3-5-23/h1-5,17-20,22,24,32H,6-16,21H2/t32-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.				J Med Chem 42: 2651-61 (1999) Article DOI: 10.1021/jm990059k BindingDB Entry DOI: 10.7270/Q2ST7P2V
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50079082 (1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...) Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)S(=O)(=O)Cc3ccccc3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C33H36Br2ClN3O3S/c34-27-17-26-7-6-25-18-28(36)19-29(35)31(25)32(33(26)37-20-27)24-10-12-38(13-11-24)30(40)16-22-8-14-39(15-9-22)43(41,42)21-23-4-2-1-3-5-23/h1-5,17-20,22,24,32H,6-16,21H2/t32-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17.1	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against Hras Farnesyltransferase (FPT).				J Med Chem 42: 2651-61 (1999) Article DOI: 10.1021/jm990059k BindingDB Entry DOI: 10.7270/Q2ST7P2V
					More data for this Ligand-Target Pair