BindingDB logo
myBDB logout

null

SMILES: CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2ccc(cc2)[N+]([O-])=O)c1)C(O)=O

InChI Key: InChIKey=SMFRBSRYCWADEI-QFIPXVFZSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50079675   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50079675
PNG
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-(4-nitro-benzy...)
Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2ccc(cc2)[N+]([O-])=O)c1)C(O)=O
Show InChI InChI=1S/C24H27N5O5S/c1-35-10-9-22(24(31)32)27-23(30)19-4-2-3-18(11-19)14-28(15-20-12-25-16-26-20)13-17-5-7-21(8-6-17)29(33)34/h2-8,11-12,16,22H,9-10,13-15H2,1H3,(H,25,26)(H,27,30)(H,31,32)/t22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 27n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras.

Bioorg Med Chem Lett 9: 1991-6 (1999)


BindingDB Entry DOI: 10.7270/Q2ZG6RFB
More data for this
Ligand-Target Pair