null
SMILES: CCCC[C@H]1CN(Oc2cccc(c2)C(F)(F)F)C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N
InChI Key: InChIKey=RYQUTFHCUCTHFO-QHCPKHFHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50081212 (4-{5-[(S)-2-Butyl-5-oxo-4-(3-trifluoromethyl-pheno...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]-GGPP incorporation into recombinant human RhoA by Geranylgeranyl transferase type I | J Med Chem 42: 3779-84 (1999) BindingDB Entry DOI: 10.7270/Q2F47NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human)) | BDBM50081212 (4-{5-[(S)-2-Butyl-5-oxo-4-(3-trifluoromethyl-pheno...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase | J Med Chem 42: 3779-84 (1999) BindingDB Entry DOI: 10.7270/Q2F47NB1 | |||||||||||
More data for this Ligand-Target Pair |