BDBM50085254 1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidine::CHEMBL423811
SMILES: Clc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
InChI Key: InChIKey=VARRYIIVLBTVMO-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM50085254 (1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gyeongsang National University (GNU) Curated by ChEMBL | Assay Description Inhibition of human leukotriene A4 hydrolase | Eur J Med Chem 46: 1593-603 (2011) Article DOI: 10.1016/j.ejmech.2011.02.007 BindingDB Entry DOI: 10.7270/Q2K64JDG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM50085254 (1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development Curated by ChEMBL | Assay Description Inhibitory activity was determined against Leukotriene A4 hydrolase | J Med Chem 43: 721-35 (2000) BindingDB Entry DOI: 10.7270/Q2CN74MZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM50085254 (1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development Curated by ChEMBL | Assay Description Inhibitory activity was determined for LTB4 production in human whole blood. | J Med Chem 43: 721-35 (2000) BindingDB Entry DOI: 10.7270/Q2CN74MZ | |||||||||||
More data for this Ligand-Target Pair |