BDBM50087006 8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(2-oxo-2-phenyl-ethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL26483

SMILES: Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1

InChI Key: InChIKey=XDBSOVFDSPYHQJ-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50087006   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50087006 (8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...) Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1 Show InChI InChI=1S/C31H32ClN3O2/c32-28-13-7-10-23-14-15-26(20-27(23)28)33-18-16-31(17-19-33)30(37)34(21-29(36)24-8-3-1-4-9-24)22-35(31)25-11-5-2-6-12-25/h1-13,26H,14-22H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50087006 (8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...) Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1 Show InChI InChI=1S/C31H32ClN3O2/c32-28-13-7-10-23-14-15-26(20-27(23)28)33-18-16-31(17-19-33)30(37)34(21-29(36)24-8-3-1-4-9-24)22-35(31)25-11-5-2-6-12-25/h1-13,26H,14-22H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50087006 (8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...) Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1 Show InChI InChI=1S/C31H32ClN3O2/c32-28-13-7-10-23-14-15-26(20-27(23)28)33-18-16-31(17-19-33)30(37)34(21-29(36)24-8-3-1-4-9-24)22-35(31)25-11-5-2-6-12-25/h1-13,26H,14-22H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50087006 (8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...) Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1 Show InChI InChI=1S/C31H32ClN3O2/c32-28-13-7-10-23-14-15-26(20-27(23)28)33-18-16-31(17-19-33)30(37)34(21-29(36)24-8-3-1-4-9-24)22-35(31)25-11-5-2-6-12-25/h1-13,26H,14-22H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
					More data for this Ligand-Target Pair