BDBM50089822 4-(3-Chloro-4-methoxy-benzylamino)-1-[(pyridin-3-ylmethyl)-amino]-phthalazine-6-carbonitrile; hydrochloride::CHEMBL544546

SMILES: COc1ccc(CNc2nnc(NCc3cccnc3)c3ccc(cc23)C#N)cc1Cl

InChI Key: InChIKey=ZFFJPACCXSDXFH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50089822   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50089822 (4-(3-Chloro-4-methoxy-benzylamino)-1-[(pyridin-3-y...) Show SMILES COc1ccc(CNc2nnc(NCc3cccnc3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H19ClN6O/c1-31-21-7-5-16(10-20(21)24)13-27-23-19-9-15(11-25)4-6-18(19)22(29-30-23)28-14-17-3-2-8-26-12-17/h2-10,12H,13-14H2,1H3,(H,27,30)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Company, Ltd. Curated by ChEMBL					Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets				J Med Chem 43: 2523-9 (2000) BindingDB Entry DOI: 10.7270/Q2T72J4N
					More data for this Ligand-Target Pair