BDBM50091955 3-(2-Diethylamino-ethoxy)-5a,11a-dihydro-benzo[b]naphtho[2,3-d]furan-6,11-dione::CHEMBL292475

SMILES: CCN(CC)CCOc1ccc2c(c1)oc1c(O)c3ccccc3c(O)c21

InChI Key: InChIKey=RLDUSFODMUWPNX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50091955   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50091955 (3-(2-Diethylamino-ethoxy)-5a,11a-dihydro-benzo[b]n...) Show SMILES CCN(CC)CCOc1ccc2c(c1)oc1c(O)c3ccccc3c(O)c21 Show InChI InChI=1S/C22H23NO4/c1-3-23(4-2)11-12-26-14-9-10-17-18(13-14)27-22-19(17)20(24)15-7-5-6-8-16(15)21(22)25/h5-10,13,24-25H,3-4,11-12H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article	n/a	n/a	6.92E+9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of telomerase (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-011-9594-4 BindingDB Entry DOI: 10.7270/Q2X63QV3
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50091955 (3-(2-Diethylamino-ethoxy)-5a,11a-dihydro-benzo[b]n...) Show SMILES CCN(CC)CCOc1ccc2c(c1)oc1c(O)c3ccccc3c(O)c21 Show InChI InChI=1S/C22H23NO4/c1-3-23(4-2)11-12-26-14-9-10-17-18(13-14)27-22-19(17)20(24)15-7-5-6-8-16(15)21(22)25/h5-10,13,24-25H,3-4,11-12H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Reading University Curated by ChEMBL					Assay Description Inhibitory activity of the compound was tested against human ovarian cancer cell (A2780 cells) Telomerase				Bioorg Med Chem Lett 10: 2063-6 (2000) BindingDB Entry DOI: 10.7270/Q25T3JQM
					More data for this Ligand-Target Pair