BDBM50094529 2-Benzyl-4,6-diphenyl-1,2,3,5-tetrahydro-pyrrolo[3,4-c]pyrrole::2-benzyl-4,6-diphenyl-1,2,3,5-tetrahydropyrrolo[3,4-c]pyrrole::CHEMBL140206

SMILES: C(N1Cc2c(C1)c([nH]c2-c1ccccc1)-c1ccccc1)c1ccccc1

InChI Key: InChIKey=XPZIIJVAVYDHEE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50094529   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse))	BDBM50094529 (2-Benzyl-4,6-diphenyl-1,2,3,5-tetrahydro-pyrrolo[3...) Show SMILES C(N1Cc2c(C1)c([nH]c2-c1ccccc1)-c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H22N2/c1-4-10-19(11-5-1)16-27-17-22-23(18-27)25(21-14-8-3-9-15-21)26-24(22)20-12-6-2-7-13-20/h1-15,26H,16-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Dr HS Gour University Curated by ChEMBL					Assay Description Inhibition of mouse macrophage COX2				Eur J Med Chem 43: 1559-69 (2008) Article DOI: 10.1016/j.ejmech.2007.09.028 BindingDB Entry DOI: 10.7270/Q2M909WP
					More data for this Ligand-Target Pair
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse))	BDBM50094529 (2-Benzyl-4,6-diphenyl-1,2,3,5-tetrahydro-pyrrolo[3...) Show SMILES C(N1Cc2c(C1)c([nH]c2-c1ccccc1)-c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H22N2/c1-4-10-19(11-5-1)16-27-17-22-23(18-27)25(21-14-8-3-9-15-21)26-24(22)20-12-6-2-7-13-20/h1-15,26H,16-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherche Servier Curated by ChEMBL					Assay Description Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophages				J Med Chem 43: 4582-93 (2001) BindingDB Entry DOI: 10.7270/Q23B60T1
					More data for this Ligand-Target Pair