BindingDB PrimarySearch

BDBM50099692 CHEMBL51314::N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide::N-(9,10-Dioxo-9,10-dihydro-phenanthrene-2-yl)-2,2-dimethyl-propionamide::N-(9,10-dioxo-9,10-dihydrophenanthren-2-yl)-2,2-dimethylpropionamide

SMILES: CC(C)(C)C(=O)Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21

InChI Key: InChIKey=VZQDDSYKVYARDW-UHFFFAOYSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50099692
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Leukocyte common antigen (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
United States Army Medical Research Institute of Infectious Diseases					Assay Description Protein phosphatases were purchased from Upstate Biotechnology (Lake Placid, NY).				J Biol Chem 284: 12874-85 (2009) Article DOI: 10.1074/jbc.M809633200 BindingDB Entry DOI: 10.7270/Q2J67FJV
					More data for this Ligand-Target Pair
Fas-associated protein-tyrosine phosphatase 1 (FAP1) (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against FAP-1 pNPP				J Med Chem 44: 1777-93 (2001) BindingDB Entry DOI: 10.7270/Q2X34WQQ
AstraZeneca Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against Cathepsin S				J Med Chem 44: 1777-93 (2001) BindingDB Entry DOI: 10.7270/Q2X34WQQ
AstraZeneca Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Leukocyte common antigen (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against CD45 protein-tyrosine phosphatase using lck-10 mer as substrate				J Med Chem 44: 1777-93 (2001) BindingDB Entry DOI: 10.7270/Q2X34WQQ
AstraZeneca Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Fas-associated protein-tyrosine phosphatase 1 (FAP1) (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against FAP-1 using lck-10 mer as substrate				J Med Chem 44: 1777-93 (2001) BindingDB Entry DOI: 10.7270/Q2X34WQQ
AstraZeneca Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Fas-associated protein-tyrosine phosphatase 1 (FAP1) (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of protein tyrosine phosphatase N13 (unknown origin) phosphorylation				J Biol Chem 282: 35361-72 (2007) Article DOI: 10.1074/jbc.M706923200 BindingDB Entry DOI: 10.7270/Q25M65HF
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against Cathepsin B				J Med Chem 44: 1777-93 (2001) BindingDB Entry DOI: 10.7270/Q2X34WQQ
AstraZeneca Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Leukocyte common antigen (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate				J Med Chem 44: 1777-93 (2001) BindingDB Entry DOI: 10.7270/Q2X34WQQ
AstraZeneca Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against Cathepsin L				J Med Chem 44: 1777-93 (2001) BindingDB Entry DOI: 10.7270/Q2X34WQQ
AstraZeneca Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of Lck (unknown origin) phosphorylation				J Biol Chem 282: 35361-72 (2007) Article DOI: 10.1074/jbc.M706923200 BindingDB Entry DOI: 10.7270/Q25M65HF
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of protein tyrosine phosphatase N1 (unknown origin) phosphorylation				J Biol Chem 282: 35361-72 (2007) Article DOI: 10.1074/jbc.M706923200 BindingDB Entry DOI: 10.7270/Q25M65HF
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50099692 (CHEMBL51314 \| N-(9,10-Dioxo-9,10-dihydro-phenanthr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Inhibitory concentration against PTP1B using lck as substrate				J Med Chem 44: 1777-93 (2001) BindingDB Entry DOI: 10.7270/Q2X34WQQ
AstraZeneca Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair