BDBM50102025 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID::CHEMBL291678::[(R)-4-((E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,20-dioxo-17-(S)-oxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid::[4-((10R,16S)-18-(S)-1-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid::[4-(18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid
SMILES: NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)C[C@H](\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(CP(O)(O)=O)cc1
InChI Key: InChIKey=RHYFMOCFCFUTNH-GZNVFMSSSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Grb2-SH2 (Homo sapiens (Human)) | BDBM50102025 (4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health Curated by ChEMBL | Assay Description Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in ELISA | Bioorg Med Chem Lett 11: 1889-92 (2001) BindingDB Entry DOI: 10.7270/Q2BV7FW1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Grb2-SH2 (Homo sapiens (Human)) | BDBM50102025 (4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute Curated by ChEMBL | Assay Description In vitro binding affinity in extracellular ELISA-based assay for Grb2 SH2 domain | J Med Chem 47: 788-91 (2004) Article DOI: 10.1021/jm030440b BindingDB Entry DOI: 10.7270/Q2XD114Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Grb2-SH2 (Homo sapiens (Human)) | BDBM50102025 (4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAP...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute Curated by ChEMBL | Assay Description Inhibition of Growth factor receptor bound protein 2 SH2 domain in extracellular binding assay | J Med Chem 46: 2621-30 (2003) Article DOI: 10.1021/jm030049q BindingDB Entry DOI: 10.7270/Q2C828PT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |