Found 7 hits for monomerid = 50102469 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50102469
(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)Show SMILES COCCOC(=O)N1CCC(CC1)C(N(Cc1ccccn1)S(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C30H35N3O8S/c1-39-19-20-41-30(36)32-17-14-24(15-18-32)28(29(34)35)33(21-25-5-3-4-16-31-25)42(37,38)27-12-8-23(9-13-27)22-6-10-26(40-2)11-7-22/h3-13,16,24,28H,14-15,17-21H2,1-2H3,(H,34,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against matrix metalloprotease-2 |
J Med Chem 44: 2499-502 (2001)
BindingDB Entry DOI: 10.7270/Q2Z89D47 |
More data for this
Ligand-Target Pair | |
Matrilysin
(Homo sapiens (Human)) | BDBM50102469
(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)Show SMILES COCCOC(=O)N1CCC(CC1)C(N(Cc1ccccn1)S(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C30H35N3O8S/c1-39-19-20-41-30(36)32-17-14-24(15-18-32)28(29(34)35)33(21-25-5-3-4-16-31-25)42(37,38)27-12-8-23(9-13-27)22-6-10-26(40-2)11-7-22/h3-13,16,24,28H,14-15,17-21H2,1-2H3,(H,34,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 3.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against matrix metalloprotease-7 |
J Med Chem 44: 2499-502 (2001)
BindingDB Entry DOI: 10.7270/Q2Z89D47 |
More data for this
Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50102469
(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)Show SMILES COCCOC(=O)N1CCC(CC1)C(N(Cc1ccccn1)S(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C30H35N3O8S/c1-39-19-20-41-30(36)32-17-14-24(15-18-32)28(29(34)35)33(21-25-5-3-4-16-31-25)42(37,38)27-12-8-23(9-13-27)22-6-10-26(40-2)11-7-22/h3-13,16,24,28H,14-15,17-21H2,1-2H3,(H,34,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 86.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against matrix metalloprotease-3 |
J Med Chem 44: 2499-502 (2001)
BindingDB Entry DOI: 10.7270/Q2Z89D47 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50102469
(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)Show SMILES COCCOC(=O)N1CCC(CC1)C(N(Cc1ccccn1)S(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C30H35N3O8S/c1-39-19-20-41-30(36)32-17-14-24(15-18-32)28(29(34)35)33(21-25-5-3-4-16-31-25)42(37,38)27-12-8-23(9-13-27)22-6-10-26(40-2)11-7-22/h3-13,16,24,28H,14-15,17-21H2,1-2H3,(H,34,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 18.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of human matrix metalloprotease-9 |
J Med Chem 44: 2499-502 (2001)
BindingDB Entry DOI: 10.7270/Q2Z89D47 |
More data for this
Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50102469
(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)Show SMILES COCCOC(=O)N1CCC(CC1)C(N(Cc1ccccn1)S(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C30H35N3O8S/c1-39-19-20-41-30(36)32-17-14-24(15-18-32)28(29(34)35)33(21-25-5-3-4-16-31-25)42(37,38)27-12-8-23(9-13-27)22-6-10-26(40-2)11-7-22/h3-13,16,24,28H,14-15,17-21H2,1-2H3,(H,34,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 3.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against matrix metalloprotease-1 |
J Med Chem 44: 2499-502 (2001)
BindingDB Entry DOI: 10.7270/Q2Z89D47 |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50102469
(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)Show SMILES COCCOC(=O)N1CCC(CC1)C(N(Cc1ccccn1)S(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C30H35N3O8S/c1-39-19-20-41-30(36)32-17-14-24(15-18-32)28(29(34)35)33(21-25-5-3-4-16-31-25)42(37,38)27-12-8-23(9-13-27)22-6-10-26(40-2)11-7-22/h3-13,16,24,28H,14-15,17-21H2,1-2H3,(H,34,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against matrix metalloprotease-13 |
J Med Chem 44: 2499-502 (2001)
BindingDB Entry DOI: 10.7270/Q2Z89D47 |
More data for this
Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50102469
(4-{Carboxy-[(4'-methoxy-biphenyl-4-sulfonyl)-pyrid...)Show SMILES COCCOC(=O)N1CCC(CC1)C(N(Cc1ccccn1)S(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C30H35N3O8S/c1-39-19-20-41-30(36)32-17-14-24(15-18-32)28(29(34)35)33(21-25-5-3-4-16-31-25)42(37,38)27-12-8-23(9-13-27)22-6-10-26(40-2)11-7-22/h3-13,16,24,28H,14-15,17-21H2,1-2H3,(H,34,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against matrix metalloprotease-8 |
J Med Chem 44: 2499-502 (2001)
BindingDB Entry DOI: 10.7270/Q2Z89D47 |
More data for this
Ligand-Target Pair | |
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