BDBM50103185 CHEMBL3393194

SMILES: COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4cccnc4)c(C)c3)c2cc1OC

InChI Key: InChIKey=FEGRSUIQAKRFCI-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50103185   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50103185 (CHEMBL3393194) Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4cccnc4)c(C)c3)c2cc1OC Show InChI InChI=1S/C26H27N5O3/c1-17-11-18(21-16-29-30-22-13-24(34-3)23(33-2)12-20(21)22)14-28-25(17)31-9-6-26(32,7-10-31)19-5-4-8-27-15-19/h4-5,8,11-16,32H,6-7,9-10H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...				Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (Human))	BDBM50103185 (CHEMBL3393194) Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4cccnc4)c(C)c3)c2cc1OC Show InChI InChI=1S/C26H27N5O3/c1-17-11-18(21-16-29-30-22-13-24(34-3)23(33-2)12-20(21)22)14-28-25(17)31-9-6-26(32,7-10-31)19-5-4-8-27-15-19/h4-5,8,11-16,32H,6-7,9-10H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.11E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...				Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50103185 (CHEMBL3393194) Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4cccnc4)c(C)c3)c2cc1OC Show InChI InChI=1S/C26H27N5O3/c1-17-11-18(21-16-29-30-22-13-24(34-3)23(33-2)12-20(21)22)14-28-25(17)31-9-6-26(32,7-10-31)19-5-4-8-27-15-19/h4-5,8,11-16,32H,6-7,9-10H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...				Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50103185 (CHEMBL3393194) Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4cccnc4)c(C)c3)c2cc1OC Show InChI InChI=1S/C26H27N5O3/c1-17-11-18(21-16-29-30-22-13-24(34-3)23(33-2)12-20(21)22)14-28-25(17)31-9-6-26(32,7-10-31)19-5-4-8-27-15-19/h4-5,8,11-16,32H,6-7,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra...				Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM50103185 (CHEMBL3393194) Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4cccnc4)c(C)c3)c2cc1OC Show InChI InChI=1S/C26H27N5O3/c1-17-11-18(21-16-29-30-22-13-24(34-3)23(33-2)12-20(21)22)14-28-25(17)31-9-6-26(32,7-10-31)19-5-4-8-27-15-19/h4-5,8,11-16,32H,6-7,9-10H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci...				Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N
					More data for this Ligand-Target Pair