Found 4 hits for monomerid = 50105887 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105887
(CHEMBL2370553 | Cyclo Ac-Cys-Glu-His-D-(2')Nal-Arg...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:82.89,89.97,4.3,57.61,42.44,101.109,31.33,wD:9.81,92.105,17.17,67.72,(.52,-47.48,;1.54,-48.63,;1.05,-50.09,;3.04,-48.33,;3.52,-46.86,;5.04,-47.18,;6.57,-47.12,;8.06,-46.67,;9.39,-45.91,;10.5,-44.85,;11.33,-43.55,;11.81,-42.09,;13.33,-42.39,;11.93,-40.55,;11.7,-39.03,;11.09,-37.61,;12.42,-36.84,;10.16,-36.38,;11.28,-35.31,;12.75,-35.73,;13.97,-34.79,;15.24,-35.66,;14.82,-37.14,;15.63,-38.45,;14.9,-39.8,;13.35,-39.85,;12.55,-38.55,;13.27,-37.19,;8.97,-35.4,;7.58,-34.74,;8.06,-33.28,;6.06,-34.43,;6.19,-32.89,;7.58,-32.24,;7.71,-30.7,;9.11,-30.04,;9.23,-28.5,;10.62,-27.84,;7.95,-27.63,;4.53,-34.5,;3.05,-34.91,;2.45,-33.51,;1.71,-35.7,;.79,-34.46,;.78,-32.93,;2.1,-32.14,;2.1,-30.61,;.75,-29.86,;.73,-28.32,;-.61,-27.57,;-1.93,-28.36,;-1.91,-29.88,;-.57,-30.65,;-.55,-32.17,;.61,-36.75,;-.23,-38.06,;-1.62,-37.41,;-.71,-39.53,;-2.23,-39.22,;-2.7,-37.76,;-1.81,-36.5,;-2.72,-35.26,;-4.18,-35.75,;-4.18,-37.29,;-.83,-41.06,;-.58,-42.58,;-2.06,-43.01,;.02,-44,;-1.32,-44.76,;-2.65,-44,;-3.98,-44.76,;-5.32,-44,;-3.98,-46.3,;.94,-45.23,;2.14,-46.21,;1.31,-47.5,;11.7,-45.81,;11.44,-47.34,;13.14,-45.28,;13.05,-43.74,;14.49,-43.2,;15.45,-44.39,;14.62,-45.67,;15.17,-47.12,;14.2,-48.3,;16.7,-47.35,;16.61,-45.81,;18.05,-45.25,;19.01,-46.46,;18.17,-47.75,;18.94,-49.07,;18.16,-50.4,;20.48,-49.07,;21.25,-47.75,;20.48,-46.41,;21.25,-45.08,;20.48,-43.74,;21.26,-42.41,;21.24,-50.4,;22.77,-50.4,;23.55,-49.07,;23.54,-51.74,;25.08,-51.75,;22.76,-53.05,;23.53,-54.41,;22.76,-55.73,;25.06,-54.41,)| Show InChI InChI=1S/C70H93N19O16S2/c1-38(90)80-53-35-106-107-36-54(68(104)89-26-10-18-56(89)69(105)88-25-9-17-55(88)60(96)47(15-6-7-23-71)82-61(97)45(72)31-59(94)95)81-57(91)34-78-62(98)51(29-42-32-77-46-14-5-4-13-44(42)46)86-63(99)48(16-8-24-76-70(73)74)83-65(101)50(28-39-19-20-40-11-2-3-12-41(40)27-39)85-66(102)52(30-43-33-75-37-79-43)87-64(100)49(84-67(53)103)21-22-58(92)93/h2-5,11-14,19-20,27,32-33,37,45,47-56,77H,6-10,15-18,21-26,28-31,34-36,71-72H2,1H3,(H,75,79)(H,78,98)(H,80,90)(H,81,91)(H,82,97)(H,83,101)(H,84,103)(H,85,102)(H,86,99)(H,87,100)(H,92,93)(H,94,95)(H4,73,74,76)/t45?,47?,48-,49+,50-,51+,52-,53+,54-,55?,56?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5 (MC5R)
(Homo sapiens (Human)) | BDBM50105887
(CHEMBL2370553 | Cyclo Ac-Cys-Glu-His-D-(2')Nal-Arg...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:82.89,89.97,4.3,57.61,42.44,101.109,31.33,wD:9.81,92.105,17.17,67.72,(.52,-47.48,;1.54,-48.63,;1.05,-50.09,;3.04,-48.33,;3.52,-46.86,;5.04,-47.18,;6.57,-47.12,;8.06,-46.67,;9.39,-45.91,;10.5,-44.85,;11.33,-43.55,;11.81,-42.09,;13.33,-42.39,;11.93,-40.55,;11.7,-39.03,;11.09,-37.61,;12.42,-36.84,;10.16,-36.38,;11.28,-35.31,;12.75,-35.73,;13.97,-34.79,;15.24,-35.66,;14.82,-37.14,;15.63,-38.45,;14.9,-39.8,;13.35,-39.85,;12.55,-38.55,;13.27,-37.19,;8.97,-35.4,;7.58,-34.74,;8.06,-33.28,;6.06,-34.43,;6.19,-32.89,;7.58,-32.24,;7.71,-30.7,;9.11,-30.04,;9.23,-28.5,;10.62,-27.84,;7.95,-27.63,;4.53,-34.5,;3.05,-34.91,;2.45,-33.51,;1.71,-35.7,;.79,-34.46,;.78,-32.93,;2.1,-32.14,;2.1,-30.61,;.75,-29.86,;.73,-28.32,;-.61,-27.57,;-1.93,-28.36,;-1.91,-29.88,;-.57,-30.65,;-.55,-32.17,;.61,-36.75,;-.23,-38.06,;-1.62,-37.41,;-.71,-39.53,;-2.23,-39.22,;-2.7,-37.76,;-1.81,-36.5,;-2.72,-35.26,;-4.18,-35.75,;-4.18,-37.29,;-.83,-41.06,;-.58,-42.58,;-2.06,-43.01,;.02,-44,;-1.32,-44.76,;-2.65,-44,;-3.98,-44.76,;-5.32,-44,;-3.98,-46.3,;.94,-45.23,;2.14,-46.21,;1.31,-47.5,;11.7,-45.81,;11.44,-47.34,;13.14,-45.28,;13.05,-43.74,;14.49,-43.2,;15.45,-44.39,;14.62,-45.67,;15.17,-47.12,;14.2,-48.3,;16.7,-47.35,;16.61,-45.81,;18.05,-45.25,;19.01,-46.46,;18.17,-47.75,;18.94,-49.07,;18.16,-50.4,;20.48,-49.07,;21.25,-47.75,;20.48,-46.41,;21.25,-45.08,;20.48,-43.74,;21.26,-42.41,;21.24,-50.4,;22.77,-50.4,;23.55,-49.07,;23.54,-51.74,;25.08,-51.75,;22.76,-53.05,;23.53,-54.41,;22.76,-55.73,;25.06,-54.41,)| Show InChI InChI=1S/C70H93N19O16S2/c1-38(90)80-53-35-106-107-36-54(68(104)89-26-10-18-56(89)69(105)88-25-9-17-55(88)60(96)47(15-6-7-23-71)82-61(97)45(72)31-59(94)95)81-57(91)34-78-62(98)51(29-42-32-77-46-14-5-4-13-44(42)46)86-63(99)48(16-8-24-76-70(73)74)83-65(101)50(28-39-19-20-40-11-2-3-12-41(40)27-39)85-66(102)52(30-43-33-75-37-79-43)87-64(100)49(84-67(53)103)21-22-58(92)93/h2-5,11-14,19-20,27,32-33,37,45,47-56,77H,6-10,15-18,21-26,28-31,34-36,71-72H2,1H3,(H,75,79)(H,78,98)(H,80,90)(H,81,91)(H,82,97)(H,83,101)(H,84,103)(H,85,102)(H,86,99)(H,87,100)(H,92,93)(H,94,95)(H4,73,74,76)/t45?,47?,48-,49+,50-,51+,52-,53+,54-,55?,56?/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50105887
(CHEMBL2370553 | Cyclo Ac-Cys-Glu-His-D-(2')Nal-Arg...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:82.89,89.97,4.3,57.61,42.44,101.109,31.33,wD:9.81,92.105,17.17,67.72,(.52,-47.48,;1.54,-48.63,;1.05,-50.09,;3.04,-48.33,;3.52,-46.86,;5.04,-47.18,;6.57,-47.12,;8.06,-46.67,;9.39,-45.91,;10.5,-44.85,;11.33,-43.55,;11.81,-42.09,;13.33,-42.39,;11.93,-40.55,;11.7,-39.03,;11.09,-37.61,;12.42,-36.84,;10.16,-36.38,;11.28,-35.31,;12.75,-35.73,;13.97,-34.79,;15.24,-35.66,;14.82,-37.14,;15.63,-38.45,;14.9,-39.8,;13.35,-39.85,;12.55,-38.55,;13.27,-37.19,;8.97,-35.4,;7.58,-34.74,;8.06,-33.28,;6.06,-34.43,;6.19,-32.89,;7.58,-32.24,;7.71,-30.7,;9.11,-30.04,;9.23,-28.5,;10.62,-27.84,;7.95,-27.63,;4.53,-34.5,;3.05,-34.91,;2.45,-33.51,;1.71,-35.7,;.79,-34.46,;.78,-32.93,;2.1,-32.14,;2.1,-30.61,;.75,-29.86,;.73,-28.32,;-.61,-27.57,;-1.93,-28.36,;-1.91,-29.88,;-.57,-30.65,;-.55,-32.17,;.61,-36.75,;-.23,-38.06,;-1.62,-37.41,;-.71,-39.53,;-2.23,-39.22,;-2.7,-37.76,;-1.81,-36.5,;-2.72,-35.26,;-4.18,-35.75,;-4.18,-37.29,;-.83,-41.06,;-.58,-42.58,;-2.06,-43.01,;.02,-44,;-1.32,-44.76,;-2.65,-44,;-3.98,-44.76,;-5.32,-44,;-3.98,-46.3,;.94,-45.23,;2.14,-46.21,;1.31,-47.5,;11.7,-45.81,;11.44,-47.34,;13.14,-45.28,;13.05,-43.74,;14.49,-43.2,;15.45,-44.39,;14.62,-45.67,;15.17,-47.12,;14.2,-48.3,;16.7,-47.35,;16.61,-45.81,;18.05,-45.25,;19.01,-46.46,;18.17,-47.75,;18.94,-49.07,;18.16,-50.4,;20.48,-49.07,;21.25,-47.75,;20.48,-46.41,;21.25,-45.08,;20.48,-43.74,;21.26,-42.41,;21.24,-50.4,;22.77,-50.4,;23.55,-49.07,;23.54,-51.74,;25.08,-51.75,;22.76,-53.05,;23.53,-54.41,;22.76,-55.73,;25.06,-54.41,)| Show InChI InChI=1S/C70H93N19O16S2/c1-38(90)80-53-35-106-107-36-54(68(104)89-26-10-18-56(89)69(105)88-25-9-17-55(88)60(96)47(15-6-7-23-71)82-61(97)45(72)31-59(94)95)81-57(91)34-78-62(98)51(29-42-32-77-46-14-5-4-13-44(42)46)86-63(99)48(16-8-24-76-70(73)74)83-65(101)50(28-39-19-20-40-11-2-3-12-41(40)27-39)85-66(102)52(30-43-33-75-37-79-43)87-64(100)49(84-67(53)103)21-22-58(92)93/h2-5,11-14,19-20,27,32-33,37,45,47-56,77H,6-10,15-18,21-26,28-31,34-36,71-72H2,1H3,(H,75,79)(H,78,98)(H,80,90)(H,81,91)(H,82,97)(H,83,101)(H,84,103)(H,85,102)(H,86,99)(H,87,100)(H,92,93)(H,94,95)(H4,73,74,76)/t45?,47?,48-,49+,50-,51+,52-,53+,54-,55?,56?/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5 (MC5R)
(Homo sapiens (Human)) | BDBM50105887
(CHEMBL2370553 | Cyclo Ac-Cys-Glu-His-D-(2')Nal-Arg...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:82.89,89.97,4.3,57.61,42.44,101.109,31.33,wD:9.81,92.105,17.17,67.72,(.52,-47.48,;1.54,-48.63,;1.05,-50.09,;3.04,-48.33,;3.52,-46.86,;5.04,-47.18,;6.57,-47.12,;8.06,-46.67,;9.39,-45.91,;10.5,-44.85,;11.33,-43.55,;11.81,-42.09,;13.33,-42.39,;11.93,-40.55,;11.7,-39.03,;11.09,-37.61,;12.42,-36.84,;10.16,-36.38,;11.28,-35.31,;12.75,-35.73,;13.97,-34.79,;15.24,-35.66,;14.82,-37.14,;15.63,-38.45,;14.9,-39.8,;13.35,-39.85,;12.55,-38.55,;13.27,-37.19,;8.97,-35.4,;7.58,-34.74,;8.06,-33.28,;6.06,-34.43,;6.19,-32.89,;7.58,-32.24,;7.71,-30.7,;9.11,-30.04,;9.23,-28.5,;10.62,-27.84,;7.95,-27.63,;4.53,-34.5,;3.05,-34.91,;2.45,-33.51,;1.71,-35.7,;.79,-34.46,;.78,-32.93,;2.1,-32.14,;2.1,-30.61,;.75,-29.86,;.73,-28.32,;-.61,-27.57,;-1.93,-28.36,;-1.91,-29.88,;-.57,-30.65,;-.55,-32.17,;.61,-36.75,;-.23,-38.06,;-1.62,-37.41,;-.71,-39.53,;-2.23,-39.22,;-2.7,-37.76,;-1.81,-36.5,;-2.72,-35.26,;-4.18,-35.75,;-4.18,-37.29,;-.83,-41.06,;-.58,-42.58,;-2.06,-43.01,;.02,-44,;-1.32,-44.76,;-2.65,-44,;-3.98,-44.76,;-5.32,-44,;-3.98,-46.3,;.94,-45.23,;2.14,-46.21,;1.31,-47.5,;11.7,-45.81,;11.44,-47.34,;13.14,-45.28,;13.05,-43.74,;14.49,-43.2,;15.45,-44.39,;14.62,-45.67,;15.17,-47.12,;14.2,-48.3,;16.7,-47.35,;16.61,-45.81,;18.05,-45.25,;19.01,-46.46,;18.17,-47.75,;18.94,-49.07,;18.16,-50.4,;20.48,-49.07,;21.25,-47.75,;20.48,-46.41,;21.25,-45.08,;20.48,-43.74,;21.26,-42.41,;21.24,-50.4,;22.77,-50.4,;23.55,-49.07,;23.54,-51.74,;25.08,-51.75,;22.76,-53.05,;23.53,-54.41,;22.76,-55.73,;25.06,-54.41,)| Show InChI InChI=1S/C70H93N19O16S2/c1-38(90)80-53-35-106-107-36-54(68(104)89-26-10-18-56(89)69(105)88-25-9-17-55(88)60(96)47(15-6-7-23-71)82-61(97)45(72)31-59(94)95)81-57(91)34-78-62(98)51(29-42-32-77-46-14-5-4-13-44(42)46)86-63(99)48(16-8-24-76-70(73)74)83-65(101)50(28-39-19-20-40-11-2-3-12-41(40)27-39)85-66(102)52(30-43-33-75-37-79-43)87-64(100)49(84-67(53)103)21-22-58(92)93/h2-5,11-14,19-20,27,32-33,37,45,47-56,77H,6-10,15-18,21-26,28-31,34-36,71-72H2,1H3,(H,75,79)(H,78,98)(H,80,90)(H,81,91)(H,82,97)(H,83,101)(H,84,103)(H,85,102)(H,86,99)(H,87,100)(H,92,93)(H,94,95)(H4,73,74,76)/t45?,47?,48-,49+,50-,51+,52-,53+,54-,55?,56?/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 42 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Increase in intracellular cAMP in CHO cells expressing human melanocortin receptor 5. |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
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