BindingDB PrimarySearch_ki

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null

SMILES: Cc1cn(C2OC(CO[Si](C)(C)C(C)(C)C)CC2O[Si](C)(C)C(C)(C)C)c(=O)n(CC(O)=O)c1=O

InChI Key: InChIKey=IHXAFBNVJSPXTN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50106919
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50106919 (CHEMBL105018 \| {3-[3-(tert-Butyl-dimethyl-silanylo...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh School of Medicine Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity				J Med Chem 49: 4834-41 (2006) Article DOI: 10.1021/jm0604575 BindingDB Entry DOI: 10.7270/Q2GH9HKC
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50106919 (CHEMBL105018 \| {3-[3-(tert-Butyl-dimethyl-silanylo...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh School of Medicine Curated by ChEMBL					Assay Description Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerization				J Med Chem 49: 4834-41 (2006) Article DOI: 10.1021/jm0604575 BindingDB Entry DOI: 10.7270/Q2GH9HKC
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50106919 (CHEMBL105018 \| {3-[3-(tert-Butyl-dimethyl-silanylo...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description The compound was evaluated for inhibition of HIV-1 wild types GluL38-Lys recombinant reverse transcriptase				Bioorg Med Chem Lett 11: 3085-8 (2001) BindingDB Entry DOI: 10.7270/Q2QC02S2
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50106919 (CHEMBL105018 \| {3-[3-(tert-Butyl-dimethyl-silanylo...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description The compound was evaluated for inhibition of HIV-1 wild types GluL38-Lys recombinant reverse transcriptase				Bioorg Med Chem Lett 11: 3085-8 (2001) BindingDB Entry DOI: 10.7270/Q2QC02S2
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50106919 (CHEMBL105018 \| {3-[3-(tert-Butyl-dimethyl-silanylo...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Effective concentration required to inhibit HIV-1 induced cytopathicity by 50% in CEM cells				Bioorg Med Chem Lett 11: 3085-8 (2001) BindingDB Entry DOI: 10.7270/Q2QC02S2
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					More data for this Ligand-Target Pair