BDBM50107559 CHEMBL168904::N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-2-propyl-5-p-tolyl-pyrimidin-4-yl}-4-tert-butyl-benzenesulfonamide
SMILES: CCCc1nc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c(c(OCCOc2ncc(Br)cn2)n1)-c1ccc(C)cc1
InChI Key: InChIKey=BHSAHNPXJBATRX-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelin receptor ET-A (Sus scrofa) | BDBM50107559 (CHEMBL168904 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Co. Ltd. Curated by ChEMBL | Assay Description In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane. | Bioorg Med Chem Lett 12: 81-4 (2001) BindingDB Entry DOI: 10.7270/Q2VX0FSC | |||||||||||
More data for this Ligand-Target Pair |