BDBM50108153 CHEMBL306276::N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-N-hydroxy-formamide

SMILES: ON(C=O)C(CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1)C1CCC2(CC1)OCCO2

InChI Key: InChIKey=HUVXWBYSMDRXQZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50108153   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50108153 (CHEMBL306276 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...) Show SMILES ON(C=O)C(CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1)C1CCC2(CC1)OCCO2 Show InChI InChI=1S/C24H26F3NO8S/c25-24(26,27)36-20-3-1-18(2-4-20)35-19-5-7-21(8-6-19)37(31,32)15-22(28(30)16-29)17-9-11-23(12-10-17)33-13-14-34-23/h1-8,16-17,22,30H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50108153 (CHEMBL306276 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...) Show SMILES ON(C=O)C(CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1)C1CCC2(CC1)OCCO2 Show InChI InChI=1S/C24H26F3NO8S/c25-24(26,27)36-20-3-1-18(2-4-20)35-19-5-7-21(8-6-19)37(31,32)15-22(28(30)16-29)17-9-11-23(12-10-17)33-13-14-34-23/h1-8,16-17,22,30H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MMP9				ACS Med Chem Lett 2: 455-460 (2011) Article DOI: 10.1021/ml200031m BindingDB Entry DOI: 10.7270/Q2HQ40ZK
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50108153 (CHEMBL306276 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...) Show SMILES ON(C=O)C(CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1)C1CCC2(CC1)OCCO2 Show InChI InChI=1S/C24H26F3NO8S/c25-24(26,27)36-20-3-1-18(2-4-20)35-19-5-7-21(8-6-19)37(31,32)15-22(28(30)16-29)17-9-11-23(12-10-17)33-13-14-34-23/h1-8,16-17,22,30H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50108153 (CHEMBL306276 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...) Show SMILES ON(C=O)C(CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1)C1CCC2(CC1)OCCO2 Show InChI InChI=1S/C24H26F3NO8S/c25-24(26,27)36-20-3-1-18(2-4-20)35-19-5-7-21(8-6-19)37(31,32)15-22(28(30)16-29)17-9-11-23(12-10-17)33-13-14-34-23/h1-8,16-17,22,30H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair