BDBM50108658 1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexahydropyridine)]-3-one::CHEMBL343793
SMILES: O=C1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
InChI Key: InChIKey=RZXNEAPKBXXMQP-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50108658![]() (1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmazeutisches Institut der Universität Freiburg Curated by ChEMBL | Assay Description Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand. | J Med Chem 45: 438-48 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig)) | BDBM50108658![]() (1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wilhelms-Universit£t M£nster Curated by ChEMBL | Assay Description Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis | Bioorg Med Chem 21: 1844-56 (2013) Article DOI: 10.1016/j.bmc.2013.01.038 BindingDB Entry DOI: 10.7270/Q2JH3NJX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50108658![]() (1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmazeutisches Institut der Universität Freiburg Curated by ChEMBL | Assay Description Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand | J Med Chem 45: 438-48 (2002) BindingDB Entry DOI: 10.7270/Q2VT1RDH | |||||||||||
More data for this Ligand-Target Pair |