BDBM50111492 CHEMBL3604942

SMILES: CN1CCN(CC1)c1cc(Nc2n[nH]c3ccccc23)nc(n1)-c1cccc(NC(=O)C=C)c1

InChI Key: InChIKey=UMEGSGXZXLWQMC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50111492   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50111492 (CHEMBL3604942) Show SMILES CN1CCN(CC1)c1cc(Nc2n[nH]c3ccccc23)nc(n1)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C25H26N8O/c1-3-23(34)26-18-8-6-7-17(15-18)24-27-21(16-22(29-24)33-13-11-32(2)12-14-33)28-25-19-9-4-5-10-20(19)30-31-25/h3-10,15-16H,1,11-14H2,2H3,(H,26,34)(H2,27,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TU Dortmund University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-...				J Med Chem 58: 6844-63 (2015) BindingDB Entry DOI: 10.7270/Q2WM1G59
					More data for this Ligand-Target Pair