BDBM50112172 CHEMBL3608427

SMILES: [Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCCO)cc2)(CCCc2ccc(OCC(=O)NCCCO)cc2)C1

InChI Key: InChIKey=DDNJBCVKJFTXST-JMAPEOGHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50112172   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amiloride-sensitive sodium channel subunit alpha (Mus musculus)	BDBM50112172 (CHEMBL3608427) Show SMILES [Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCCO)cc2)(CCCc2ccc(OCC(=O)NCCCO)cc2)C1 |r| Show InChI InChI=1S/C38H53ClN8O7.ClH/c39-35-37(41)46-36(40)34(45-35)38(52)44-29-8-3-21-47(24-29,19-1-6-27-9-13-30(14-10-27)53-25-32(50)42-17-4-22-48)20-2-7-28-11-15-31(16-12-28)54-26-33(51)43-18-5-23-49;/h9-16,29,48-49H,1-8,17-26H2,(H6-,40,41,42,43,44,46,50,51,52);1H/t29-;/m0./s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...				ACS Med Chem Lett 6: 729-31 (2015) BindingDB Entry DOI: 10.7270/Q2348N52
					More data for this Ligand-Target Pair