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BDBM50115329 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid (4-phenoxy-phenyl)-amide::CHEMBL104896

SMILES: COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC

InChI Key: InChIKey=MZLOJIXBFDLLQO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50115329   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta)


(Homo sapiens (human))
BDBM50115329
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H27N5O3S/c1-33-24-16-22-23(17-25(24)34-2)28-18-29-26(22)31-12-14-32(15-13-31)27(36)30-19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/a 370n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation


Citation and Details
More data for this
Ligand-Target Pair