BDBM50116621 3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicyclo[3.3.1]non-5-yl]-phenol::CHEMBL333342
SMILES: CC1CN(CCCc2ccccc2)C2C[C@H](N)CC1(C2)c1cccc(O)c1
InChI Key: InChIKey=DBPFGWTUHBQYTM-LGZXGLGHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Ability to displace [3H]DAMGO from Opioid receptor mu 1 of rat brain | J Med Chem 45: 3524-30 (2002) BindingDB Entry DOI: 10.7270/Q2959J8R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 14.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Ability to displace [3H]DADLE from Opioid receptor delta 1 of rat brain | J Med Chem 45: 3524-30 (2002) BindingDB Entry DOI: 10.7270/Q2959J8R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 122 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Ability to displace [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brain | J Med Chem 45: 3524-30 (2002) BindingDB Entry DOI: 10.7270/Q2959J8R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 207 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Ability to displace [3H]DAMGO from Opioid receptor mu 1 of rat brain | J Med Chem 45: 3524-30 (2002) BindingDB Entry DOI: 10.7270/Q2959J8R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 246 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Ability to displace [3H]DADLE from Opioid receptor delta 1 of rat brain | J Med Chem 45: 3524-30 (2002) BindingDB Entry DOI: 10.7270/Q2959J8R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 893 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Ability to displace [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brain | J Med Chem 45: 3524-30 (2002) BindingDB Entry DOI: 10.7270/Q2959J8R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.95E+4 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Agonist activity at human cloned mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTP[gammaS] binding | Bioorg Med Chem Lett 24: 2021-32 (2014) Article DOI: 10.1016/j.bmcl.2014.03.040 BindingDB Entry DOI: 10.7270/Q2222WBX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Agonist activity at human cloned kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTP[gammaS] binding | Bioorg Med Chem Lett 24: 2021-32 (2014) Article DOI: 10.1016/j.bmcl.2014.03.040 BindingDB Entry DOI: 10.7270/Q2222WBX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50116621 (3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Agonist activity at human cloned delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTP[gammaS] binding | Bioorg Med Chem Lett 24: 2021-32 (2014) Article DOI: 10.1016/j.bmcl.2014.03.040 BindingDB Entry DOI: 10.7270/Q2222WBX | |||||||||||
More data for this Ligand-Target Pair |