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SMILES: Cn1cc(Cc2cn(CC(=O)N(CCN3CCOCC3)Cc3ccc(cc3)-c3ccc(Cl)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1

InChI Key: InChIKey=WHTMZPVPXYRTDK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50117803   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor acetylhydrolase


(Homo sapiens (Human))		BDBM50117803
PNG
(CHEMBL328064 | N-(4'-Chloro-biphenyl-4-ylmethyl)-2...)
Show SMILES Cn1cc(Cc2cn(CC(=O)N(CCN3CCOCC3)Cc3ccc(cc3)-c3ccc(Cl)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1
Show InChI InChI=1S/C37H38ClFN6O3S/c1-42-22-29(21-40-42)20-32-24-45(37(41-36(32)47)49-26-28-4-12-34(39)13-5-28)25-35(46)44(15-14-43-16-18-48-19-17-43)23-27-2-6-30(7-3-27)31-8-10-33(38)11-9-31/h2-13,21-22,24H,14-20,23,25-26H2,1H3
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PubMed
n/an/a 1.40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimated

Bioorg Med Chem Lett 12: 2603-6 (2002)


BindingDB Entry DOI: 10.7270/Q2G44PNN
More data for this
Ligand-Target Pair