BDBM50119286 3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a]azulen-9-one::CHEMBL319170::PD-146626::kb-NB165-09
SMILES: COc1ccc2sc3c(SCCNC3=O)c2c1
InChI Key: InChIKey=KGMSYXGSYGEHIS-UHFFFAOYSA-N
Data: 8 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 82.5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Pittsburgh | Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences. | BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D2 (Homo sapiens (Human)) | BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 142 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Pittsburgh | Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences. | BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D3 (Homo sapiens (Human)) | BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 98.5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Pittsburgh | Assay Description In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences. | BMC Chem Biol 10: 5 (2010) Article DOI: 10.1186/1472-6769-10-5 BindingDB Entry DOI: 10.7270/Q2VQ315D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 82.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Inhibition of human recombinant PKD1 after 10 mins by radiometric assay | ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 1 (Homo sapiens (Human)) | BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of CDK2 | Bioorg Med Chem Lett 19: 4878-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.015 BindingDB Entry DOI: 10.7270/Q28K795K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-activated protein kinase 2 (Homo sapiens (Human)) | BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha production | Bioorg Med Chem Lett 19: 4878-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.015 BindingDB Entry DOI: 10.7270/Q28K795K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D1 (Homo sapiens (Human)) | BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blotting | ACS Med Chem Lett 2: 154-159 (2012) Article DOI: 10.1021/ml100230n BindingDB Entry DOI: 10.7270/Q29G5NTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-activated protein kinase 2 (Homo sapiens (Human)) | BDBM50119286 (3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of MK2 | Bioorg Med Chem Lett 19: 4878-81 (2009) Article DOI: 10.1016/j.bmcl.2009.02.015 BindingDB Entry DOI: 10.7270/Q28K795K | |||||||||||
More data for this Ligand-Target Pair |