BDBM50121885 (S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-(carbamoylmethyl-carbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide::Bu-His-DPhe-Arg-Trp-Gly-NH2::CHEMBL29582
SMILES: CCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O
InChI Key: InChIKey=LVACOVVOTCZAIW-JVVMDBNWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanocyte-stimulating hormone receptor (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Agonist activity against human melanocortin receptor hMC1R at 50% maximum cAMP accumulation | Bioorg Med Chem Lett 13: 133-7 (2002) BindingDB Entry DOI: 10.7270/Q2BV7H5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Binding affinity towards human melanocortin receptor hMC4R by using radioligand NDP-MSH | Bioorg Med Chem Lett 13: 133-7 (2002) BindingDB Entry DOI: 10.7270/Q2BV7H5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Effective concentration for cAMP accumulation mediated by human Melanocortin 4 receptor in HEK293 cells | Bioorg Med Chem Lett 15: 4910-4 (2005) Article DOI: 10.1016/j.bmcl.2005.08.012 BindingDB Entry DOI: 10.7270/Q28915D1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 3 (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Binding affinity towards human Melanocortin 3 receptor using radiolabeled NDP-MSH displacement | Bioorg Med Chem Lett 15: 4910-4 (2005) Article DOI: 10.1016/j.bmcl.2005.08.012 BindingDB Entry DOI: 10.7270/Q28915D1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocyte-stimulating hormone receptor (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Binding affinity towards human Melanocortin 1 receptor using radiolabeled NDP-MSH displacement | Bioorg Med Chem Lett 15: 4910-4 (2005) Article DOI: 10.1016/j.bmcl.2005.08.012 BindingDB Entry DOI: 10.7270/Q28915D1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Binding affinity towards human Melanocortin 4 receptor using radiolabeled NDP-MSH displacement | Bioorg Med Chem Lett 15: 4910-4 (2005) Article DOI: 10.1016/j.bmcl.2005.08.012 BindingDB Entry DOI: 10.7270/Q28915D1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (MC5R) (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Binding affinity towards human Melanocortin 5 receptor using radiolabeled NDP-MSH displacement | Bioorg Med Chem Lett 15: 4910-4 (2005) Article DOI: 10.1016/j.bmcl.2005.08.012 BindingDB Entry DOI: 10.7270/Q28915D1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocyte-stimulating hormone receptor (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Effective concentration required for cAMP accumulation mediated by human Melanocortin 1 receptor in HEK293 cells | Bioorg Med Chem Lett 15: 4910-4 (2005) Article DOI: 10.1016/j.bmcl.2005.08.012 BindingDB Entry DOI: 10.7270/Q28915D1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Agonist activity in HEK293 cells transfected with human MC4R by cAMP accumulation | Bioorg Med Chem Lett 15: 5504-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.083 BindingDB Entry DOI: 10.7270/Q2MC8ZK7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocyte-stimulating hormone receptor (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Agonist activity in HEK293 cells transfected with human MC1R by cAMP accumulation | Bioorg Med Chem Lett 15: 5504-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.083 BindingDB Entry DOI: 10.7270/Q2MC8ZK7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (MC5R) (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Binding affinity towards human melanocortin receptor hMC5R by using radioligand NDP-MSH | Bioorg Med Chem Lett 13: 133-7 (2002) BindingDB Entry DOI: 10.7270/Q2BV7H5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Agonist activity against human melanocortin receptor hMC4R | Bioorg Med Chem Lett 13: 133-7 (2002) BindingDB Entry DOI: 10.7270/Q2BV7H5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocyte-stimulating hormone receptor (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Binding affinity towards human melanocortin receptor hMC4R by using radioligand NDP-MSH; not determined | Bioorg Med Chem Lett 13: 133-7 (2002) BindingDB Entry DOI: 10.7270/Q2BV7H5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocyte-stimulating hormone receptor (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Agonist activity against human melanocortin receptor hMC1R | Bioorg Med Chem Lett 13: 133-7 (2002) BindingDB Entry DOI: 10.7270/Q2BV7H5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 3 (Homo sapiens (Human)) | BDBM50121885 ((S)-2-{(R)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Binding affinity towards human melanocortin receptor hMC3R by using radioligand NDP-MSH | Bioorg Med Chem Lett 13: 133-7 (2002) BindingDB Entry DOI: 10.7270/Q2BV7H5F | |||||||||||
More data for this Ligand-Target Pair |