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BDBM50123298 2-Ethyl-8-methoxy-6-(pyridin-2-ylmethoxy)-3-thioxo-2,3-dihydro-imidazo[1,5-a]indol-1-one::CHEMBL423208

SMILES: CCN1C(=O)c2cc3c(OC)cc(OCc4ccccn4)cc3n2C1=S

InChI Key: InChIKey=AUFFFZCSPVFHSE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50123298   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tumor necrosis factor receptor R1


(Homo sapiens (Human))
BDBM50123298
PNG
(2-Ethyl-8-methoxy-6-(pyridin-2-ylmethoxy)-3-thioxo...)
Show SMILES CCN1C(=O)c2cc3c(OC)cc(OCc4ccccn4)cc3n2C1=S
Show InChI InChI=1S/C19H17N3O3S/c1-3-21-18(23)16-10-14-15(22(16)19(21)26)8-13(9-17(14)24-2)25-11-12-6-4-5-7-20-12/h4-10H,3,11H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 310n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of TNF-alpha binding to TNFRc1


Bioorg Med Chem Lett 13: 533-8 (2003)


BindingDB Entry DOI: 10.7270/Q2X929N3
More data for this
Ligand-Target Pair