BDBM50123583 CHEMBL3622206

SMILES: [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1

InChI Key: InChIKey=KTRYUWPHTHSFQT-ZYHUDNBSSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50123583   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50123583 (CHEMBL3622206) Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay				Bioorg Med Chem Lett 25: 4642-7 (2015) BindingDB Entry DOI: 10.7270/Q2XD13HG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50123583 (CHEMBL3622206) Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	161	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...				Bioorg Med Chem Lett 25: 4642-7 (2015) BindingDB Entry DOI: 10.7270/Q2XD13HG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50123583 (CHEMBL3622206) Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	298	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...				Bioorg Med Chem Lett 25: 4642-7 (2015) BindingDB Entry DOI: 10.7270/Q2XD13HG
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50123583 (CHEMBL3622206) Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	576	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of aurora A kinase (unknown origin) by enzymatic assay				Bioorg Med Chem Lett 25: 4642-7 (2015) BindingDB Entry DOI: 10.7270/Q2XD13HG
					More data for this Ligand-Target Pair