BDBM50124807 CHEMBL3622944

SMILES: COc1c(C)cc(Nc2nccc(n2)-n2cc(C)c(CN3CC(O)C3)c2)cc1C

InChI Key: InChIKey=RONFVMXRUVHNQN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50124807   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50124807 (CHEMBL3622944) Show SMILES COc1c(C)cc(Nc2nccc(n2)-n2cc(C)c(CN3CC(O)C3)c2)cc1C Show InChI InChI=1S/C22H27N5O2/c1-14-7-18(8-15(2)21(14)29-4)24-22-23-6-5-20(25-22)27-9-16(3)17(11-27)10-26-12-19(28)13-26/h5-9,11,19,28H,10,12-13H2,1-4H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	25
Kangwon National University Curated by ChEMBL					Assay Description Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...				Bioorg Med Chem Lett 25: 4441-6 (2015) BindingDB Entry DOI: 10.7270/Q22Z17BN
					More data for this Ligand-Target Pair