BDBM50125604 1-[9-Benzyl-2-(2-fluoro-phenyl)-9H-purin-6-yl]-1-(2,6-difluoro-phenyl)-urea::CHEMBL17131
SMILES: NC(=O)N(c1nc(nc2n(Cc3ccccc3)cnc12)-c1ccccc1F)c1c(F)cccc1F
InChI Key: InChIKey=AWOCDZSZTOHVGQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM50125604 (1-[9-Benzyl-2-(2-fluoro-phenyl)-9H-purin-6-yl]-1-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human MAP p38-alpha kinase in vitro. | Bioorg Med Chem Lett 13: 1191-4 (2003) BindingDB Entry DOI: 10.7270/Q2MG7NW6 | |||||||||||
More data for this Ligand-Target Pair |