BDBM50126463 (6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-p-tolyl-2,3,6,7,12,12a-hexahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione::CHEMBL34744

SMILES: Cc1ccc(cc1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(CC2=O)[C@@H]1CCN(Cc2ccccc2)C1

InChI Key: InChIKey=JUIQWFAFVNBCAY-HVOSOHGQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50126463   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50126463 ((6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-p-tol...) Show SMILES Cc1ccc(cc1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(CC2=O)[C@@H]1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C32H32N4O2/c1-21-11-13-23(14-12-21)31-30-26(25-9-5-6-10-27(25)33-30)17-28-32(38)35(20-29(37)36(28)31)24-15-16-34(19-24)18-22-7-3-2-4-8-22/h2-14,24,28,31,33H,15-20H2,1H3/t24-,28-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 5 (PDE5) obtained from human corpus cavernosum tissue				Bioorg Med Chem Lett 13: 1425-8 (2003) BindingDB Entry DOI: 10.7270/Q2GM86N6
					More data for this Ligand-Target Pair
Phosphodiesterase 11A (PDE11A) (Homo sapiens (Human))	BDBM50126463 ((6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-p-tol...) Show SMILES Cc1ccc(cc1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(CC2=O)[C@@H]1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C32H32N4O2/c1-21-11-13-23(14-12-21)31-30-26(25-9-5-6-10-27(25)33-30)17-28-32(38)35(20-29(37)36(28)31)24-15-16-34(19-24)18-22-7-3-2-4-8-22/h2-14,24,28,31,33H,15-20H2,1H3/t24-,28-,31-/m1/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression				Bioorg Med Chem Lett 13: 1425-8 (2003) BindingDB Entry DOI: 10.7270/Q2GM86N6
					More data for this Ligand-Target Pair