BDBM50128792 5-Amino-4-(3-bromo-phenyl)-6-(4-hydroxy-phenyl)-1-pyridin-3-ylmethyl-piperidin-2-one::CHEMBL433139

SMILES: N[C@H]1C(CC(=O)N(Cc2cccnc2)[C@@H]1c1ccc(O)cc1)c1cccc(Br)c1

InChI Key: InChIKey=IWCOMUSIVDXXJY-XGELLPRESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50128792   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50128792 (5-Amino-4-(3-bromo-phenyl)-6-(4-hydroxy-phenyl)-1-...) Show SMILES N[C@H]1C(CC(=O)N(Cc2cccnc2)[C@@H]1c1ccc(O)cc1)c1cccc(Br)c1 Show InChI InChI=1S/C23H22BrN3O2/c24-18-5-1-4-17(11-18)20-12-21(29)27(14-15-3-2-10-26-13-15)23(22(20)25)16-6-8-19(28)9-7-16/h1-11,13,20,22-23,28H,12,14,25H2/t20?,22-,23+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras				J Med Chem 46: 2467-73 (2003) Article DOI: 10.1021/jm020522k BindingDB Entry DOI: 10.7270/Q2RN3775
					More data for this Ligand-Target Pair