BDBM50132679 CHEMBL111128::Methyl-((2S,3S)-3-naphthalen-2-yl-bicyclo[2.2.1]hept-2-ylmethyl)-amine
SMILES: CNC[C@H]1C2CCC(C2)[C@@H]1c1ccc2ccccc2c1
InChI Key: InChIKey=PORDAYLSLHLTRQ-FYOYPEGLSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Centre Curated by ChEMBL | Assay Description Displacement of [3H]-citalopram from Serotonin transporter | Bioorg Med Chem Lett 13: 3277-80 (2003) BindingDB Entry DOI: 10.7270/Q29W0DXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Centre Curated by ChEMBL | Assay Description Displacement of [3H]-WIN-35,428 from Dopamine transporter | Bioorg Med Chem Lett 13: 3277-80 (2003) BindingDB Entry DOI: 10.7270/Q29W0DXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Centre Curated by ChEMBL | Assay Description Compound was tested for its ability to displace [3H]-citalopram from norepinephrin transpoter | Bioorg Med Chem Lett 13: 3277-80 (2003) BindingDB Entry DOI: 10.7270/Q29W0DXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocon Bristol-Myers Squibb R&D Centre Curated by ChEMBL | Assay Description Inhibition of SERT (unknown origin) assessed as reduction of [3H]5-HT re-uptake | J Med Chem 61: 2133-2165 (2018) Article DOI: 10.1021/acs.jmedchem.6b01827 BindingDB Entry DOI: 10.7270/Q2BV7K8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocon Bristol-Myers Squibb R&D Centre Curated by ChEMBL | Assay Description Inhibition of NET (unknown origin) assessed as reduction of [3H]-NE re-uptake | J Med Chem 61: 2133-2165 (2018) Article DOI: 10.1021/acs.jmedchem.6b01827 BindingDB Entry DOI: 10.7270/Q2BV7K8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocon Bristol-Myers Squibb R&D Centre Curated by ChEMBL | Assay Description Inhibition of DAT (unknown origin) assessed as reduction of [3H]-DA re-uptake | J Med Chem 61: 2133-2165 (2018) Article DOI: 10.1021/acs.jmedchem.6b01827 BindingDB Entry DOI: 10.7270/Q2BV7K8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Centre Curated by ChEMBL | Assay Description Displacement of [3H]-Nisoxetine from norepinephrin transpoter | Bioorg Med Chem Lett 13: 3277-80 (2003) BindingDB Entry DOI: 10.7270/Q29W0DXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Centre Curated by ChEMBL | Assay Description In vitro inhibition of [3H]-NE re-uptake into synaptosome | Bioorg Med Chem Lett 13: 3277-80 (2003) BindingDB Entry DOI: 10.7270/Q29W0DXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50132679![]() (CHEMBL111128 | Methyl-((2S,3S)-3-naphthalen-2-yl-b...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Centre Curated by ChEMBL | Assay Description In vitro ability of compound to inhibit 5-HT re-uptake of radiolabelled [3H]-tritium trasmitter into synaptosome | Bioorg Med Chem Lett 13: 3277-80 (2003) BindingDB Entry DOI: 10.7270/Q29W0DXF | |||||||||||
More data for this Ligand-Target Pair |