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null

SMILES: FC(F)(F)c1cccc(c1)-c1n[nH]cc1-c1ccnc2ccccc12

InChI Key: InChIKey=UZNTWHBHIHKRLK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50132986
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132986 (4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	524	n/a	n/a	n/a	n/a	n/a	n/a
The Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)				J Med Chem 46: 3953-6 (2003) Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38
The Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132986 (4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
The Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Mitogen-activated protein kinase p38				J Med Chem 46: 3953-6 (2003) Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38
The Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132986 (4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	217	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
Sichuan University Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132986 (4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	355	n/a	n/a	n/a	n/a	n/a	n/a
The Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)				J Med Chem 46: 3953-6 (2003) Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38
The Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50132986 (4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	217	n/a	n/a	n/a	n/a	n/a	n/a
The Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)				J Med Chem 46: 3953-6 (2003) Article DOI: 10.1021/jm0205705 BindingDB Entry DOI: 10.7270/Q2RV0N38
The Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair