null

SMILES: Cc1cnn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O

InChI Key: InChIKey=BVMACYSLWMRCNV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50134389   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50134389 (CHEMBL3747338) Show SMILES Cc1cnn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O Show InChI InChI=1S/C14H11Cl2N5O/c1-7-5-19-21-13(7)18-6-11(12(17)22)14(21)20-10-3-8(15)2-9(16)4-10/h2-6,20H,1H3,(H2,17,22)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Research Center Curated by ChEMBL					Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP				Bioorg Med Chem Lett 26: 454-9 (2016) BindingDB Entry DOI: 10.7270/Q2X92D4M
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50134389 (CHEMBL3747338) Show SMILES Cc1cnn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O Show InChI InChI=1S/C14H11Cl2N5O/c1-7-5-19-21-13(7)18-6-11(12(17)22)14(21)20-10-3-8(15)2-9(16)4-10/h2-6,20H,1H3,(H2,17,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay				Bioorg Med Chem Lett 26: 454-9 (2016) BindingDB Entry DOI: 10.7270/Q2X92D4M
					More data for this Ligand-Target Pair