null
SMILES: CC(C)c1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(C)(=O)=O
InChI Key: InChIKey=WGGRXSZLNZHDJO-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human)) | BDBM50134431 (CHEMBL3747181) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 507 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center Curated by ChEMBL | Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP | Bioorg Med Chem Lett 26: 454-9 (2016) BindingDB Entry DOI: 10.7270/Q2X92D4M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM50134431 (CHEMBL3747181) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research Center Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay | Bioorg Med Chem Lett 26: 454-9 (2016) BindingDB Entry DOI: 10.7270/Q2X92D4M | |||||||||||
More data for this Ligand-Target Pair |