BDBM50134654 (4-Benzyl-piperidin-1-yl)-(5,7-dihydroxy-1H-indol-2-yl)-methanone::(4-benzylpiperidine-1-yl)-(5,7-dihydroxy-1H-indole-2-yl)-methanone::CHEMBL124516

SMILES: Oc1cc(O)c2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1

InChI Key: InChIKey=MTTXNYIRSMETRQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50134654   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50134654 ((4-Benzyl-piperidin-1-yl)-(5,7-dihydroxy-1H-indol-...) Show SMILES Oc1cc(O)c2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-17-11-16-12-18(22-20(16)19(25)13-17)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
GluN1/GluN2B NMDA receptor (Homo sapiens (Human))	BDBM50134654 ((4-Benzyl-piperidin-1-yl)-(5,7-dihydroxy-1H-indol-...) Show SMILES Oc1cc(O)c2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-17-11-16-12-18(22-20(16)19(25)13-17)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B				Bioorg Med Chem Lett 13: 3859-61 (2003) BindingDB Entry DOI: 10.7270/Q2TH8M32
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50134654 ((4-Benzyl-piperidin-1-yl)-(5,7-dihydroxy-1H-indol-...) Show SMILES Oc1cc(O)c2[nH]c(cc2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-17-11-16-12-18(22-20(16)19(25)13-17)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair