BDBM50135327 (2-Bromo-4-isopropyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethyl-thiazol-2-yl}-amine::CHEMBL131422
SMILES: CCCN(CC1CC1)Cc1sc(Nc2ccc(cc2Br)C(C)C)nc1C(F)(F)F
InChI Key: InChIKey=IBAVUGWJVSMJLY-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corticotropin releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50135327 ((2-Bromo-4-isopropyl-phenyl)-{5-[(cyclopropylmethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity by displacement of [125I]-Tyr-o-CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cel... | Bioorg Med Chem Lett 13: 3997-4000 (2003) BindingDB Entry DOI: 10.7270/Q2MW2GJW | |||||||||||
More data for this Ligand-Target Pair |