BDBM50135673 3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine::CHEMBL95255

SMILES: CCN(CC)Cc1nnc2nc(N)nc(N)c2n1

InChI Key: InChIKey=YQHZTGWSLGCDMD-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50135673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 2 mM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR) (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Leukocyte antigen related receptor phosphatase (LAR) in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Tyrosine phosphatase SHP-2 in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase alpha (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Protein-tyrosine phosphatase alpha in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair