BDBM50135933 3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-propionic acid::CHEMBL302067

SMILES: Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1

InChI Key: InChIKey=IFHWJTOFROTZBD-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50135933   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)				Bioorg Med Chem Lett 14: 2141-5 (2004) Article DOI: 10.1016/j.bmcl.2004.02.033 BindingDB Entry DOI: 10.7270/Q2N8797S
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human TAF1a using hippuryl-L-arginine/hippuryl-L-lysine as substrate by liquid chromatographic analysis				Bioorg Med Chem 22: 2261-8 (2014) Article DOI: 10.1016/j.bmc.2014.02.010 BindingDB Entry DOI: 10.7270/Q2DZ09TG
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of TAF1a in human plasma assessed as clot lysis				Bioorg Med Chem 22: 2261-8 (2014) Article DOI: 10.1016/j.bmc.2014.02.010 BindingDB Entry DOI: 10.7270/Q2DZ09TG
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasma				J Med Chem 46: 5294-7 (2003) Article DOI: 10.1021/jm034141y BindingDB Entry DOI: 10.7270/Q27H1J0Z
					More data for this Ligand-Target Pair
Carboxypeptidase B (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human carboxypeptidase B (CPB)				Bioorg Med Chem Lett 14: 2141-5 (2004) Article DOI: 10.1016/j.bmcl.2004.02.033 BindingDB Entry DOI: 10.7270/Q2N8797S
					More data for this Ligand-Target Pair
Carboxypeptidase M (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of purified Carboxypeptidase M (CPM) by clot lysis assay in human plasma				J Med Chem 46: 5294-7 (2003) Article DOI: 10.1021/jm034141y BindingDB Entry DOI: 10.7270/Q27H1J0Z
					More data for this Ligand-Target Pair
Carboxypeptidase A1 (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasma				J Med Chem 46: 5294-7 (2003) Article DOI: 10.1021/jm034141y BindingDB Entry DOI: 10.7270/Q27H1J0Z
					More data for this Ligand-Target Pair
Carboxypeptidase M (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of purified Carboxypeptidase M (CPM) by clot lysis assay in human plasma				J Med Chem 46: 5294-7 (2003) Article DOI: 10.1021/jm034141y BindingDB Entry DOI: 10.7270/Q27H1J0Z
					More data for this Ligand-Target Pair
Carboxypeptidase A1 (Homo sapiens (Human))	BDBM50135933 (3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...) Show SMILES Nc1ccc(CC(C(O)=O)c2cnc[nH]2)cn1 Show InChI InChI=1S/C11H12N4O2/c12-10-2-1-7(4-14-10)3-8(11(16)17)9-5-13-6-15-9/h1-2,4-6,8H,3H2,(H2,12,14)(H,13,15)(H,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of Carboxypeptidase A (CPA) was determined by clot lysis assay using human plasma				J Med Chem 46: 5294-7 (2003) Article DOI: 10.1021/jm034141y BindingDB Entry DOI: 10.7270/Q27H1J0Z
					More data for this Ligand-Target Pair