BDBM50139472 CHEMBL3763746

SMILES: CCOC(=O)c1sc(N(Cc2cncn2Cc2ccc(cc2)C#N)C(=O)OC(C)(C)C)c(C#N)c1-c1ccc(Cl)cc1

InChI Key: InChIKey=ZABYRPJDECIZCI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50139472   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139472 (CHEMBL3763746) Show SMILES CCOC(=O)c1sc(N(Cc2cncn2Cc2ccc(cc2)C#N)C(=O)OC(C)(C)C)c(C#N)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C31H28ClN5O4S/c1-5-40-29(38)27-26(22-10-12-23(32)13-11-22)25(15-34)28(42-27)37(30(39)41-31(2,3)4)18-24-16-35-19-36(24)17-21-8-6-20(14-33)7-9-21/h6-13,16,19H,5,17-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UPR2301 Curated by ChEMBL					Assay Description Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay				Eur J Med Chem 109: 173-86 (2016) BindingDB Entry DOI: 10.7270/Q25B04C6
					More data for this Ligand-Target Pair