BDBM50143121 3-Cyclopropyl-6-(6-methyl-pyridin-2-ylmethoxy)-[1,2,4]triazolo[3,4-a]phthalazine::CHEMBL296383

SMILES: Cc1cccc(COc2nn3c(nnc3c3ccccc23)C2CC2)n1

InChI Key: InChIKey=OBPPXGLDCMXNDT-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50143121   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GABA receptor alpha-5/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50143121 (3-Cyclopropyl-6-(6-methyl-pyridin-2-ylmethoxy)-[1,...) Show SMILES Cc1cccc(COc2nn3c(nnc3c3ccccc23)C2CC2)n1 Show InChI InChI=1S/C19H17N5O/c1-12-5-4-6-14(20-12)11-25-19-16-8-3-2-7-15(16)18-22-21-17(13-9-10-13)24(18)23-19/h2-8,13H,9-11H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits in L(tk-) cells				J Med Chem 47: 1807-22 (2004) Article DOI: 10.1021/jm031020p BindingDB Entry DOI: 10.7270/Q2959H0R
					More data for this Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50143121 (3-Cyclopropyl-6-(6-methyl-pyridin-2-ylmethoxy)-[1,...) Show SMILES Cc1cccc(COc2nn3c(nnc3c3ccccc23)C2CC2)n1 Show InChI InChI=1S/C19H17N5O/c1-12-5-4-6-14(20-12)11-25-19-16-8-3-2-7-15(16)18-22-21-17(13-9-10-13)24(18)23-19/h2-8,13H,9-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity for human GABA-A receptor alpha3-beta3-gamma2 subunits in L(tk-) cells				J Med Chem 47: 1807-22 (2004) Article DOI: 10.1021/jm031020p BindingDB Entry DOI: 10.7270/Q2959H0R
					More data for this Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50143121 (3-Cyclopropyl-6-(6-methyl-pyridin-2-ylmethoxy)-[1,...) Show SMILES Cc1cccc(COc2nn3c(nnc3c3ccccc23)C2CC2)n1 Show InChI InChI=1S/C19H17N5O/c1-12-5-4-6-14(20-12)11-25-19-16-8-3-2-7-15(16)18-22-21-17(13-9-10-13)24(18)23-19/h2-8,13H,9-11H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits in L(tk-) cells				J Med Chem 47: 1807-22 (2004) Article DOI: 10.1021/jm031020p BindingDB Entry DOI: 10.7270/Q2959H0R
					More data for this Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50143121 (3-Cyclopropyl-6-(6-methyl-pyridin-2-ylmethoxy)-[1,...) Show SMILES Cc1cccc(COc2nn3c(nnc3c3ccccc23)C2CC2)n1 Show InChI InChI=1S/C19H17N5O/c1-12-5-4-6-14(20-12)11-25-19-16-8-3-2-7-15(16)18-22-21-17(13-9-10-13)24(18)23-19/h2-8,13H,9-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits in L(tk-) cells				J Med Chem 47: 1807-22 (2004) Article DOI: 10.1021/jm031020p BindingDB Entry DOI: 10.7270/Q2959H0R
					More data for this Ligand-Target Pair