BDBM50147315 2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-(2-methoxyethyl)-3-methylisoxazol-5(2H)-one::2-[4-(3-Fluoro-phenyl)-piperidine-1-carbonyl]-4-(2-methoxy-ethyl)-3-methyl-2H-isoxazol-5-one::CHEMBL106375
SMILES: COCCc1c(C)n(oc1=O)C(=O)N1CCC(CC1)c1cccc(F)c1
InChI Key: InChIKey=QSQAUXAPFAEVSV-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hormone-sensitive lipase (HSL) (Homo sapiens (Human)) | BDBM50147315 (2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-(2-m...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center Curated by ChEMBL | Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL) | Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hormone sensitive lipase (Homo sapiens (Human)) | BDBM50147315 (2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-(2-m...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center Curated by ChEMBL | Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL) | Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hormone-sensitive lipase (HSL) (Rattus norvegicus (Rat)) | BDBM50147315 (2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-(2-m...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Jordan Curated by ChEMBL | Assay Description Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | J Med Chem 51: 6478-94 (2008) Article DOI: 10.1021/jm800718k BindingDB Entry DOI: 10.7270/Q23778KJ | |||||||||||
More data for this Ligand-Target Pair |