BindingDB PrimarySearch

BDBM50148764 CHEMBL3142919::[1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N-[(3-[[[(benzyloxycarbonyl)hydroxyphosphonyl]-oxy]propyl]thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

SMILES: Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)n(CCCOP(O)(=O)C(=O)OCc2ccccc2)c1=O

InChI Key: InChIKey=DDYSDFLNIDNUQI-UHFFFAOYSA-N

Data: 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50148764
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50148764 (CHEMBL3142919 \| [1-[2',5'-Bis-O-(tert-butyldimethy...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Inhibitory concentration against wild type HIV-1 reverse transcriptase (RT) using poly rC.dG as the template or primer				J Med Chem 47: 3418-26 (2004) Article DOI: 10.1021/jm031045o BindingDB Entry DOI: 10.7270/Q2B857KW
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50148764 (CHEMBL3142919 \| [1-[2',5'-Bis-O-(tert-butyldimethy...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (IQM, CSIC) Curated by ChEMBL					Assay Description Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 mins				Eur J Med Chem 150: 206-227 (2018) Article DOI: 10.1016/j.ejmech.2018.03.007 BindingDB Entry DOI: 10.7270/Q2D79F0J
Instituto de Qu£mica M£dica (IQM, CSIC) Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50148764 (CHEMBL3142919 \| [1-[2',5'-Bis-O-(tert-butyldimethy...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.93E+5	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (IQM, CSIC) Curated by ChEMBL					Assay Description Inhibition of TSAO resistant HIV1 3B reverse transcriptase E138K mutant using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf t...				Eur J Med Chem 150: 206-227 (2018) Article DOI: 10.1016/j.ejmech.2018.03.007 BindingDB Entry DOI: 10.7270/Q2D79F0J
Instituto de Qu£mica M£dica (IQM, CSIC) Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50148764 (CHEMBL3142919 \| [1-[2',5'-Bis-O-(tert-butyldimethy...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.12E+5	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Inhibitory concentration against wild type HIV-1/138Lys reverse transcriptase (RT) using [3H]dGTP as a radioligand				J Med Chem 47: 3418-26 (2004) Article DOI: 10.1021/jm031045o BindingDB Entry DOI: 10.7270/Q2B857KW
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					More data for this Ligand-Target Pair