BindingDB PrimarySearch

BDBM50150698 3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-1H-pyrrole-2,5-dione::3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(morpholine-4-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl]-pyrrole-2,5-dione::CHEMBL178737

SMILES: O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23

InChI Key: InChIKey=INJUVNWOFHYUIN-UHFFFAOYSA-N

Data: 14 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50150698
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of GSK3beta				J Med Chem 53: 4332-53 (2010) Article DOI: 10.1021/jm9018756 BindingDB Entry DOI: 10.7270/Q21R6QPF
Amgen, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Akt1				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human TGF-beta type II receptor				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Vascular endothelial growth factor receptor 2				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mixed lineage kinase 7 (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human MLK7				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cells				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against the Glycogen synthase kinase-3				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Glycogen synthase kinase-3 beta				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Protein kinase A beta				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Protein kinase C beta 2				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human PDK-1				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Cyclin-dependent kinase 4				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cells				Bioorg Med Chem Lett 15: 899-903 (2005) Article DOI: 10.1016/j.bmcl.2004.12.063 BindingDB Entry DOI: 10.7270/Q2H70JJG
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50150698 (3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Cyclin-dependent kinase 2				J Med Chem 47: 3934-7 (2004) Article DOI: 10.1021/jm049768a BindingDB Entry DOI: 10.7270/Q2B56KG1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair