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SMILES: Nc1nc(c(s1)-c1ccnc2ccccc12)-c1ccccc1F

InChI Key: InChIKey=XFRSTLMKCGEHNT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50151356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50151356 (4-(2-Fluoro-phenyl)-5-quinolin-4-yl-thiazol-2-ylam...) Show SMILES Nc1nc(c(s1)-c1ccnc2ccccc12)-c1ccccc1F Show InChI InChI=1S/C18H12FN3S/c19-14-7-3-1-6-13(14)16-17(23-18(20)22-16)12-9-10-21-15-8-4-2-5-11(12)15/h1-10H,(H2,20,22)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cells				J Med Chem 47: 4494-506 (2004) Article DOI: 10.1021/jm0400247 BindingDB Entry DOI: 10.7270/Q2VQ325T
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50151356 (4-(2-Fluoro-phenyl)-5-quinolin-4-yl-thiazol-2-ylam...) Show SMILES Nc1nc(c(s1)-c1ccnc2ccccc12)-c1ccccc1F Show InChI InChI=1S/C18H12FN3S/c19-14-7-3-1-6-13(14)16-17(23-18(20)22-16)12-9-10-21-15-8-4-2-5-11(12)15/h1-10H,(H2,20,22)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50151356 (4-(2-Fluoro-phenyl)-5-quinolin-4-yl-thiazol-2-ylam...) Show SMILES Nc1nc(c(s1)-c1ccnc2ccccc12)-c1ccccc1F Show InChI InChI=1S/C18H12FN3S/c19-14-7-3-1-6-13(14)16-17(23-18(20)22-16)12-9-10-21-15-8-4-2-5-11(12)15/h1-10H,(H2,20,22)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.356-4.455)				J Med Chem 47: 4494-506 (2004) Article DOI: 10.1021/jm0400247 BindingDB Entry DOI: 10.7270/Q2VQ325T
					More data for this Ligand-Target Pair